Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules.
نویسندگان
چکیده
The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with C. immitis.
منابع مشابه
Immune Response to Coccidioidomycosis and the Development of a Vaccine
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ورودعنوان ژورنال:
- Infection and immunity
دوره 66 5 شماره
صفحات -
تاریخ انتشار 1998